Abstract: Centella asiatica a perennial, aromatic medicinal herb known as “miracle elixir of life” has been used as folk
medicine and also scientifically oriented medicine. The medicinal herb, Centella asiatica (L.) Urban known as Gotu kola has
been reported to exhibit a wide range of pharmacological activities. In particular, a remarkable body of scientific research
exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment of skin diseases. Centella
asiatica has potent antioxidant and anti-inflammatory properties. The active compounds including penta-cyclic triterpenes,
mainly Madecassoside, Asiaticoside, Asiatic and Madecassoside are effective in healing skin disorders such as repairing small
wounds caused by injury or burns, heals atopic dermatitis, psoriasis, acne, eczema etc. TECA is purified standardized extract
of Centella asiatica composed of Madecassic acid, Asiaticoside, and Asiatic acid.The mechanism involve wound treatment with
TECA that collagen synthesis, fibroblast proliferation, management of keloids, regulating inflammatory cytokines and chemokines
via TGF-β /Smad Signaling, NF-κ B Signaling. This madecassoside may significantly inhibit the production of IL-1β released
by P. acnes stimulated THP-1 cells that might suppress P. acnes-induced inflammatory response. Also Centella play a pivotal
role in cosmetology treating photo-ageing skin, cellulite and striae. The C. asiatica extract regulate the metabolism happening
in the cells of the connective tissue, shows anti-inflammatory and draining activity and modulates microcirculation.
Key words: Acne, Atopic Dermatitis, Burns, Centella asiatica, Madecassoside, Photo-ageing.
"A half yearly International Journal of Biological Sciences Registered in U.S. ISSN Center at the Library of Congress"