Abstract: Aquaporins (AQPs) are one of the important class of channel proteins that specifically transport water thereby
maintaining the water homeostasis of the cells. Till date 13 mammalian AQP isoforms are known to be present. Certain AQPs
have been known to carry out the movement of small molecules such as glycerol and urea. Owing to their function, AQPs are
known to participate in a wide array of cellular processes. A number of different AQP isoforms have been found to be
expressed in different cells and tissues throughout the body depending on their functions. Studies using murine models of
AQP knockouts suggest the potential role of AQP in mammalian physiology such as urine concentration, glandular fluid
movement, formation of edema, maintenance of intraocular pressure, migration of immune cells, phagocytosis etc. Recently,
studies have been executed to evaluate the role of AQPs in the pathophysiology of various diseases with inflammatory
conditions. Some common chronic inflammatory disorders such as arthritis, asthma, inflammatory bowel diseases, peritonitis,
sepsis-induced cholestasis have been known to involve AQPs. Also, studies have shown that AQP expression is modulated in
a number of cell types in response to Lipopolysaccharide-induced inflammation. Such studies propose that modulation of
AQP can be promising therapy for conditions like neuroinflammation, obesity, as well as cancer. Nevertheless, effective AQP
modulators for clinical applications are still to be discovered. This review is thereby intended to present information on the
role of AQPs in pathophysiological processes of inflammation and therefore their potential as therapeutic target of inflammation.
Key words: Aquaporins, inflammation, lipopolysaccharide, therapeutic targets, cytokines
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